6-氯-3-羟基吡嗪-4-羧酸合成路线 （共 4 条）
反应条件
hydrogenchloride in 1,4-dioxane; water T=90°C; 20 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/94976 A1, 2012 ;
Location in patent: Page/Page column 33-34 ;
反应条件
sulfuric acid in water T=50°C; 6 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; McCONNELL, Darryl; STADTMUELLER, Heinz
Patent: WO2010/7114 A2, 2010 ;
Location in patent: Page/Page column 106-107 ;
WO 2010/007114 A2
反应条件
potassium dichromate
参考文献
Kuraishi
Pharmaceutical Bulletin, 1957 , vol. 5, p. 587,588
反应条件
sodium hydroxide; palladium on activated charcoal
Hydrogenation;
参考文献
Kuraishi
Pharmaceutical Bulletin, 1957 , vol. 5, p. 587,588
