1: With copper(l) iodide; 5,5-bis(4,5-dihydrooxazol-2-yl)nonane; cesium fluoride in N,N-dimethyl-formamide T=90°C; P=760.051 Torr; 10 h; 2: With hydrogenchloride; water in N,N-dimethyl-formamide
sodium hydrogencarbonate in tetrahydrofuran T=20 - 25°C; 48 h;
参考文献
Piper, James R.; DeGraw, Joseph I.; Colwell, William T.; Johnson, Cheryl A.; Smith, R. Lane; Waud, William R.; Sirotnak, Francis M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 377 - 384