1: sodium methylate / methanol / 3 h / 20 °C 2: Dithiothreitol; magnesium chloride / 48 h / 30 °C / pH 7 / aq. buffer; Enzymatic reaction View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: NaH / dimethylformamide<br />2: pyridine / 0 &deg;C<br />3: H₂ / Pd/C / methanol<br />4: 1H-tetrazole / CH₂Cl₂ / 5 h / -20 - 20 &deg;C<br />5: m-CPBA / CH₂Cl₂ / -40 - 20 &deg;C<br />6: 96 percent / H₂ / Pd/C / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1H-tetrazole / CH₂Cl₂ / 5 h / -20 - 20 &deg;C<br />2: m-CPBA / CH₂Cl₂ / -40 - 20 &deg;C<br />3: 96 percent / H₂ / Pd/C / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: benzene / Ambient temperature<br />2: H₂ / 10 percent Pd/C / benzene; methanol / 1 h / 760 Torr / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: pyridine / 0 &deg;C<br />2: H₂ / Pd/C / methanol<br />3: 1H-tetrazole / CH₂Cl₂ / 5 h / -20 - 20 &deg;C<br />4: m-CPBA / CH₂Cl₂ / -40 - 20 &deg;C<br />5: 96 percent / H₂ / Pd/C / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1,2,4-triazole / CH₂Cl₂ / 20 &deg;C<br />2: 30 percent H₂O₂ / tetrahydrofuran / -70 - 20 &deg;C<br />3: H₂; cyclohexylamine / Pd/C / methanol / 16 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: tetraethylammonium chloride, anhydrous NaHCO₃ / acetonitrile / 0.33 h / 55 &deg;C<br />2: benzene / Ambient temperature<br />3: H₂ / 10 percent Pd/C / benzene; methanol / 1 h / 760 Torr / Ambient temperature<br /> <br /> &nbsp;