2-(4-硝基苯基)丙酸乙酯合成路线 （共 11 条）
反应条件
1: 65 percent / H2 / Pd/C / methanol / 20 °C 2: 68 percent / 2-mercaptoethanol; benzo-1,2,3-1H-triazole / acetonitrile; H2O; various solvent(s) / 13 h 3: 75 percent / NaOH / ethanol / 2.5 h / Heating View Scheme
参考文献
Lawrence, Nicholas J.; Liddle, John; Bushell, Simon M.; Jackson, David A.
Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 457 - 464
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C;
参考文献
Lawrence, Nicholas J.; Liddle, John; Bushell, Simon M.; Jackson, David A.
Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 457 - 464
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 14 h;
参考文献
Gruenenthal GmbH
Patent: US2009/156590 A1, 2009 ;
Location in patent: Page/Page column 59 ;
US 20090156590 A1
反应条件
sulfuric acid
T=20°C; 15 h; Heating / reflux;
参考文献
Gruenenthal GmbH
Patent: US2009/156590 A1, 2009 ;
Location in patent: Page/Page column 62; 64; 65-66 ;
US 20090156590 A1
反应条件
sulfuric acid in ethanol; water; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US5981550 A1, 1999 ;
US 5981550 A
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=-5 - 0°C;
参考文献
Stahly, G. Patrick; Stahly, Barbara C.; Lilje, Kenneth C.
Journal of Organic Chemistry, 1984 , vol. 49, # 3 p. 578 - 579
反应条件
sodium chloride; sodium hydrogencarbonate in hydrochloric acid-ethanol
参考文献
Nippon Shinyaku Company, Limited; Mitsubishi Chemical Industries Limited
Patent: US4720506 A1, 1988 ;
反应条件
potassium tert-butylate in ammonia
T=-60°C; 1 h;
参考文献
Iwasaki, Genji; Saeki, Seitaro; Hamana, Masatomo
Chemistry Letters, 1986 , p. 31 - 34
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=-5°C; 0.05 h;
参考文献
Mudryk, B.; Makosza, M.
Synthesis, 1988 , # 12 p. 1007 - 1009
反应条件
1: aq. H2SO4
2: H2SO4
View Scheme
参考文献
Nannini; Giraldi; Molgora; Biasoli; Spinelli; Logemann; Dradi; Zanni; Buttinoni; Tommasini
Arzneimittel-Forschung/Drug Research, 1973 , vol. 23, # 8 p. 1090 - 1100
