反应条件
1.1: 2.93 g / aq. NaHCO3 / tetrahydrofuran / 4 h
2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C
2.2: 3.82 g / tetrahydrofuran; hexane / 16 h / Heating
3.1: 2.76 g / H2 / Pd/C / methanol / 16 h / 2844.31 Torr
4.1: aq. HCl; R-(-)-mandelic acid / dioxane / 1 h
5.1: 32.1 g / NaBH(OAc)3 / CH2Cl2 / 20 °C
6.1: H2 / Pd/C / methanol / 2585.74 Torr
View Scheme
参考文献
De Lucca, George V.; Ui, Tae Kim; Vargo, Brian J.; Duncia, John V.; Santella III, Joseph B.; Gardner, Daniel S.; Zheng, Changsheng; Liauw, Ann; Wang, Zhang; Emmett, George; Wacker, Dean A.; Welch, Patricia K.; Covington, Maryanne; Stowell, Nicole C.; Wadman, Eric A.; Das, Anuk M.; Davies, Paul; Yeleswaram, Swamy; Graden, Danielle M.; Solomon, Kimberly A.; Newton, Robert C.; Trainor, George L.; Decicco, Carl P.; Ko, Soo S.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2194 - 2211