5-(氯甲基)-3-(3-甲基苯基)-1,2,4-恶二唑合成路线 （共 4 条）
反应条件
1: NH2OH*HCl; Et3N / ethanol / Heating
2: DIEA / 1,2-dichloro-ethane / Heating
View Scheme
参考文献
Elzein, Elfatih; Kalla, Rao; Li, Xiaofen; Perry, Thao; Parkhill, Eric; Palle, Venkata; Varkhedkar, Vaibahv; Gimbel, Art; Zeng, Dewan; Lustig, David; Leung, Kwan; Zablocki, Jeff
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 302 - 306
反应条件
1: DIEA / CH2Cl2 / 24 h / 20 °C
2: toluene / 24 h / Heating
View Scheme
参考文献
Zablocki, Jeff; Kalla, Rao; Perry, Thao; Palle, Venkata; Varkhedkar, Vaibhav; Xiao, Dengming; Piscopio, Anthony; Maa, Tenning; Gimbel, Art; Hao, Jia; Chu, Nancy; Leung, Kwan; Zeng, Dewan
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 609 - 612
反应条件
N-ethyl-N,N-diisopropylamine in 1,2-dichloro-ethane
Heating;
参考文献
Elzein, Elfatih; Kalla, Rao; Li, Xiaofen; Perry, Thao; Parkhill, Eric; Palle, Venkata; Varkhedkar, Vaibahv; Gimbel, Art; Zeng, Dewan; Lustig, David; Leung, Kwan; Zablocki, Jeff
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 302 - 306
反应条件
in toluene
24 h; Heating;
参考文献
Zablocki, Jeff; Kalla, Rao; Perry, Thao; Palle, Venkata; Varkhedkar, Vaibhav; Xiao, Dengming; Piscopio, Anthony; Maa, Tenning; Gimbel, Art; Hao, Jia; Chu, Nancy; Leung, Kwan; Zeng, Dewan
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 609 - 612
