5-氯甲基-3-(2-氯苯基)-1,2,4-噁二唑合成路线 （共 4 条）
反应条件
in toluene 6 h; Heating;
参考文献
Cottrell, Denise M.; Capers, Jeffrey; Salem, Manar M.; DeLuca-Fradley, Kate; Croft, Simon L.; Werbovetz, Karl A.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2815 - 2824
反应条件
1: DIEA / CH2Cl2 / 24 h / 20 °C 2: toluene / 24 h / Heating View Scheme
参考文献
Mylari; Beyer; Scott; Aldinger; Dee; Siegel; Zembrowski
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 457 - 465
反应条件
1: NH2OH*HCl; Et3N / ethanol / Heating 2: DIEA / 1,2-dichloro-ethane / Heating View Scheme
参考文献
Cottrell, Denise M.; Capers, Jeffrey; Salem, Manar M.; DeLuca-Fradley, Kate; Croft, Simon L.; Werbovetz, Karl A.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2815 - 2824
反应条件
N-ethyl-N,N-diisopropylamine in 1,2-dichloro-ethane Heating;
参考文献
Elzein, Elfatih; Kalla, Rao; Li, Xiaofen; Perry, Thao; Parkhill, Eric; Palle, Venkata; Varkhedkar, Vaibahv; Gimbel, Art; Zeng, Dewan; Lustig, David; Leung, Kwan; Zablocki, Jeff
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 302 - 306
