反应条件
1: Carbamonitrile; 3-nitro-aniline in ethanol; water
HeatingAcidic conditions;
2: N'-(5-(3-(dimethylamino)acryloyl)-4-methylthiazol-2-yl)-N,N-dimethylformimidamide With sodium hydroxide in V methoxymethyl ester
T=125°C; 22 h; Inert atmosphere;
参考文献
Wang, Shudong; Midgley, Carol A.; Scaerou, Frederic; Grabarek, Joanna B.; Griffiths, Gary; Jackson, Wayne; Kontopidis, George; McClue, Steven J.; McInnes, Campbell; Meades, Christopher; Mezna, Mokdad; Plater, Andy; Stuart, Iain; Thomas, Mark P.; Wood, Gavin; Clarke, Rosemary G.; Blake, David G.; Zheleva, Daniella I.; Lane, David P.; Jackson, Robert C.; Glover, David M.; Fischer, Peter M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 11 p. 4367 - 4378