(S)-1-对甲苯磺酰氧基-2,3-丙二醇合成路线 （共 21 条）
反应条件
1: 90 percent / H2 / 10percent Pd/C / ethyl acetate; ethanol / 48 h 2: 1.) H5IO6, 2.) NaBH4 / 1.) THF, 1 h, RT, 2.) THF, H2O, 2 h, 0 deg C View Scheme
参考文献
Pfaendler, Hans Rudolf; Maier, Franz Karl
Liebigs Annalen der Chemie, 1989 , p. 691 - 694
反应条件
toluene-4-sulfonic acid in methanol T=60°C; 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bosetti, Aldo; Bianchi, Daniele; Cesti, Pietro; Golini, Paolo; Spezia, Sandro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 18 p. 2395 - 2398
反应条件
1: 88.2 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 2: 95.4 percent / 1 M HCl / acetone / 0.5 h / 90 - 95 °C View Scheme
参考文献
Oh, Keimei; Yamada, Kazuhiro; Yoshizawa, Yuko
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6915 - 6919
反应条件
1: 71 percent / HCl / dioxane / 12 h 2: 1.) sodium periodate, 2.) NaBH4 / 1.) H2O, dioxane, room temperature, 20 min, 2.) room temperature, 30 min View Scheme
参考文献
Jindrich, Jindrich; Holy, Antonin; Dvorakova, Hana
Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 7 p. 1645 - 1667
反应条件
1: 45 percent / various solvent(s) / 5 h / 25 °C / lipase PS on Celite 577 2: 82 percent / toluene-p-sulfonic acid (PTSA) / methanol / 3 h / 60 °C View Scheme
参考文献
Bosetti, Aldo; Bianchi, Daniele; Cesti, Pietro; Golini, Paolo; Spezia, Sandro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 18 p. 2395 - 2398
反应条件
sodium tetrahydroborate; periodic acid 1.) THF, 1 h, RT, 2.) THF, H2O, 2 h, 0 deg C; Yield given. Multistep reaction;
参考文献
Jindrich, Jindrich; Holy, Antonin; Dvorakova, Hana
Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 7 p. 1645 - 1667
反应条件
trifluorormethanesulfonic acid in acetone 1 h; Ambient temperature;
参考文献
Jindrich, Jindrich; Holy, Antonin; Dvorakova, Hana
Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 7 p. 1645 - 1667
反应条件
toluene-4-sulfonic acid in Petroleum ether 4 h; Heating;
参考文献
Bosetti, Aldo; Bianchi, Daniele; Cesti, Pietro; Golini, Paolo; Spezia, Sandro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 18 p. 2395 - 2398
反应条件
in toluene 18 h; Heating;
参考文献
Giani; Marinone; Melillo; Borsa; Tonon
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 8 p. 1139 - 1141
反应条件
sodium methylate in methanol
参考文献
Leclerc; Amlaiky; Rouot
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 1 p. 69 - 74
