2-(2-溴苯基)-2-甲基-1,3-二氧戊环合成路线 （共 11 条）
反应条件
toluene-4-sulfonic acid in toluene 18 h; Dean-StarkReflux;
参考文献
Pilgrim, Ben S.; Gatland, Alice E.; McTernan, Charlie T.; Procopiou, Panayiotis A.; Donohoe, Timothy J.
Organic Letters, 2013 , vol. 15, # 24 p. 6190 - 6193
反应条件
1: n-BuLi / tetrahydrofuran 2: TsOH / acetone View Scheme
参考文献
Murafuji; Sugihara; Moriya; Mikata; Yano
New Journal of Chemistry, 1999 , vol. 23, # 7 p. 683 - 685
反应条件
1.1: t-BuLi / tetrahydrofuran / 0.5 h / -76 °C 1.2: Se / tetrahydrofuran / 3 h / -76 - 20 °C 1.3: tetrahydrofuran / 0.25 h / 20 °C 2.1: aq. HCl / acetone / 2 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 3 p. 473 - 476
反应条件
n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 1 h;
参考文献
Murafuji, Toshihiro; Sugimoto, Kenji; Yanagimoto, Sachiko; Moriya, Tomokazu; Sugihara, Yoshikazu; Mikata, Yuji; Kato, Masako; Yano, Shigenobu
Heterocycles, 2001 , vol. 54, # 2 p. 929 - 942
反应条件
n-BuLi in tetrahydrofuran -78°C to RT, 80 min;
参考文献
Murafuji; Sugihara; Moriya; Mikata; Yano
New Journal of Chemistry, 1999 , vol. 23, # 7 p. 683 - 685
反应条件
in diethyl ether; hexane; water
反应条件
1: palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate / toluene / 24 h / 110 °C / Inert atmosphere
2: sulfuric acid / 1,4-dioxane; water / 4 h / 90 °C
3: potassium tert-butylate / diethyl ether; ammonia / 2.5 h / Inert atmosphere; Irradiation; liquid NH3
View Scheme
参考文献
Guastavino, Javier F.; Rossi, Roberto A.
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 460 - 472
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy-KI
1.) benzene/THF, 63 deg C, 2.5 h; Yield given. Multistep reaction;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4840 - 4844
反应条件
1.1: t-BuLi / tetrahydrofuran / 0.5 h / -76 °C
1.2: tetrahydrofuran / 2 h / -76 - 20 °C
2.1: aq. HCl / acetone / 2 h / Heating
View Scheme
参考文献
Comasseto, Joao V.; Omori, Alvaro T.; Porto, Andre L. M.; Andrade, Leandro H.
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 473 - 476
反应条件
1.1: Mg / tetrahydrofuran
1.2: 49 percent / tetrahydrofuran / 40 °C
2.1: 70 percent / 4-toluenesulphonic acid / tetrahydrofuran; H2O / Heating
3.1: 100 percent / Heating
4.1: 64 percent / N2H4*H2O / ethanol / Heating
View Scheme
参考文献
Sun, Yu; Hienzsch, Antje; Grasser, Jens; Herdtweck, Eberhardt; Thiel, Werner R.
Journal of Organometallic Chemistry, 2006 , vol. 691, # 3 p. 291 - 298
