6-羟基-2-甲基苯并恶唑合成路线 （共 15 条）
反应条件
isobutyramide; trichlorophosphate in acetonitrile Beckmann rearrangement;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 24 p. 4313 - 4316
反应条件
1: With hydroxylamine hydrochloride in pyridine T=20°C; 20.25 h; 2: With trichlorophosphate in isobutyramide; acetonitrile T=5 - 20°C;
参考文献
WO2004/5295 A1, ;
Page 80-81 ;
反应条件
diethyl chlorophosphate in toluene Beckmann rearrangement; 0.0833333 h; Reflux;
参考文献
Synlett, , # 9 p. 1391 - 1393
反应条件
pyridinium p-toluenesulfonate; triethylamine in ethyl acetate
参考文献
US6130217 A1, ;
US 6130217 A
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium acetate in ethanol; water; acetic acid
反应条件
phosphorus pentoxide; acetic acid T=200°C; 6 h;
参考文献
Synthesis, , # 9 p. 1373 - 1376
反应条件
isobutyramide; trichlorophosphate in acetonitrile T=30°C; 0.5 h;
参考文献
Synthesis, , vol. No. 1, p. 68 - 69
参考文献
Chemische Berichte, , vol. 35, p. 4199
反应条件
1: (i) Fe, aq. HCl, EtOH, (ii) NaOAc, (iii) /BRN= 385737/ 2: KOH / ethanol View Scheme
参考文献
Journal of medicinal chemistry, , vol. 9, # 1 p. 63 - 66
反应条件
cobalt-nickel-copper catalyst T=150°C; P=95616 Torr; Hydrogenation.Reaktion ueber mehrere Stufen;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 71,78
