5-苯基-1,2-恶唑-4-羧酸乙酯合成路线 （共 9 条）
反应条件
hydrogenchloride; water in methanol Heating;
参考文献
Herrero, M.Teresa; Tellitu, Imanol; Dominguez, Esther; Hernandez, Susana; Moreno, Isabel; SanMartin, Raul
Tetrahedron, 2002 , vol. 58, # 42 p. 8581 - 8589
反应条件
sodium hydroxide in ethanol
参考文献
Eisai Co., Ltd.
Patent: EP1216980 A1, 2002 ;
EP 1216980 A1
反应条件
1: 85 percent / water; HCl / methanol / Heating 2: thionyl chloride / toluene / Heating View Scheme
参考文献
Herrero, M.Teresa; Tellitu, Imanol; Dominguez, Esther; Hernandez, Susana; Moreno, Isabel; SanMartin, Raul
Tetrahedron, 2002 , vol. 58, # 42 p. 8581 - 8589
反应条件
hydroxylamine hydrochloride; sodium acetate in methanol
参考文献
Monsanto Company
Patent: US4243406 A1, 1981 ;
反应条件
hydroxylamine hydrochloride in ethanol
9 h; Heating;
参考文献
Strah, Sonja; Golobic, Amalija; Golic, Ljubo; Stanovnik, Branko
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1511 - 1517
反应条件
1: 91 percent / acetic acid / 0.75 h / 110 °C
2: NH2OH*HCl / ethanol / 9 h / Heating
View Scheme
参考文献
Strah, Sonja; Golobic, Amalija; Golic, Ljubo; Stanovnik, Branko
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1511 - 1517
反应条件
triethylamine in diethyl ether
参考文献
Huisgen,R.; Christl,M.
Chemische Berichte, 1973 , vol. 106, p. 3291 - 3311
反应条件
acetic anhydride
Erwaermen des erhaltenen 3-Aethoxy-2-benzoyl-acrylsaeure-aethylesters mit NH2OH in wss. Aethanol;
参考文献
Panizzi
Gazzetta Chimica Italiana, 1943 , vol. 73, p. 13,21
反应条件
sodium ethanolate in diethyl ether; ethanol
12 h; Ambient temperature;
参考文献
Schenone, Pietro; Fossa, Paola; Menozzi, Giulia
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 453 - 457
