4-(4-氰基苯氧基)苯甲酸合成路线 （共 5 条）
反应条件
Jone's reagent in acetone
Cooling with ice;
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 127 ;
WO 2010/115736 A2
反应条件
NaH in dimethyl sulfoxide
参考文献
Merck and Co., Inc.
Patent: US5981584 A1, 1999 ;
参考文献
Eli Lilly and Company
Patent: US6140352 A1, 2000 ;
US 6140352 A
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tert-butyl alcohol / 4 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / 2400.24 Torr / |Microwave irradiation
3: trifluoroacetic acid / dichloromethane / 20 °C
View Scheme
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / 2400.24 Torr / |Microwave irradiation
2: trifluoroacetic acid / dichloromethane / 20 °C
View Scheme
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
