4-溴-3-氯磺酰基苯甲酸合成路线 （共 3 条）
反应条件
chlorosulfonic acid
T=80 - 120°C; 12 - 24 h;
参考文献
ADOLOR CORPORATION
Patent: WO2007/58960 A1, 2007 ;
Location in patent: Page/Page column 80 ;
WO 2007/058960 A1
反应条件
chlorosulfonic acid
T=140°C; 4 h;
参考文献
Nie, Zhe; Perretta, Carin; Lu, Jia; Su, Ying; Margosiak, Stephen; Gajiwala, Ketan S.; Cortez, Joseph; Nikulin, Victor; Yager, Kraig M.; Appelt, Krzysztof; Chu, Shaosong
Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1596 - 1609
反应条件
ammonia; water
T=0°C; 0.25 h;
参考文献
Cherepakha, Artem; Kovtunenko, Vladimir O.; Tolmachev, Andrey; Lukin, Oleg; Nazarenko, Konstantin G.
Synthetic Communications, 2011 , vol. 41, # 13 p. 1977 - 1989
