3-甲氧基-4-硝基苯甲酸合成路线 （共 45 条）
反应条件
1: (COCl)2 / tetrahydrofuran; dimethylformamide / 1 h / 0 °C 2: NH3 / tetrahydrofuran / 0 °C 3: TFA; Et3N / tetrahydrofuran / 1 h View Scheme
参考文献
Chu, Xin-Jie; Ding, Qingjie; Jiang, Nan; Zhang, Jing; Zhang, Zhuming
Patent: US2011/269809 A1, 2011 ;
反应条件
thionyl chloride; palladium on charcoal in methanol; ethyl acetate
参考文献
Roche Bioscience, a division of Syntex (U.S.A.) LLC
Patent: US2003/158226 A1, 2003 ;
US 20030158226 A1
反应条件
1: SOCl2 2: (i) Mg, (ii) H2SO4, AcOH View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: thionyl chloride / 1 h / Heating 2: pyridine / CHCl3 / 2 h / Heating 3: 65 percent / H2 / 5percent Pd/C / ethyl acetate; ethanol / 5 h / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 111, # 20 p. 7957 - 7968
反应条件
1: thionyl chloride / 1 h / Heating 2: pyridine / CHCl3 / 2 h / Heating View Scheme
参考文献
Adams, S. R.; Kao, J. P. Y.; Tsien, R. Y.
Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 7957 - 7968
反应条件
1: thionyl chloride
3: 13 g / 85 °C / Hofmann rearrangement
View Scheme
参考文献
Shine, Henry J.; Park, Koon Ha; Brownawell, Marilyn L.; Filippo, Joseph San
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7077 - 7082
反应条件
1: 95.9 percent / conc. H2SO4 / benzene / 24 h / Heating
2: 74.6 percent / H2 / PtO2 / ethanol / 72 h / 3361.5 Torr / Ambient temperature
View Scheme
参考文献
ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying
Patent: WO2014/31784 A1, 2014 ;
反应条件
thionyl chloride in toluene
1 h; Heating / reflux;
参考文献
DEVELOGEN AKTIENGESELLSCHAFT
Patent: WO2007/59905 A2, 2007 ;
Location in patent: Page/Page column 42-43 ;
WO 2007/059905 A2
参考文献
Biogen, Inc.
Patent: US6239108 B1, 2001 ;
反应条件
in hexane; dichloromethane; N,N-dimethyl-formamide
参考文献
Hinks; Jeremy David; Takle; Andrew Kenneth; Hunt; Eric
Patent: US6020368 A1, 2000 ;
