3-甲氧基-4-硝基苯甲酸合成路线 （共 45 条）
参考文献
American Cyanamid Company
Patent: US5733905 A1, 1998 ;
Title/Abstract Full Text Show Details
American Cyanamid Company
Patent: US5516774 A1, 1996 ;
Title/Abstract Full Text Show Details
American Cyanamid Company
Patent: US5736540 A1, 1998 ;
反应条件
1: 3-Methoxy-4-nitrobenzoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine in dichloromethane
T=25°C; 1 h;
2: 1-methyl-piperidin-4-ylamine in dichloromethane
T=20°C; 16 h; Product distribution / selectivity;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/35902 A1, 2006 ;
Location in patent: Page/Page column 4 ;
反应条件
1: 3-Methoxy-4-nitrobenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: methylamine in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
DEVELOGEN AKTIENGESELLSCHAFT
Patent: WO2006/136402 A1, 2006 ;
Location in patent: Page/Page column 119-120 ;
WO 2006/136402 A1
反应条件
benzotriazol-1-ol in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2006/21454 A2, 2006 ;
Location in patent: Page/Page column 90 ;
WO 2006/021454 A2
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran
T=0 - 20°C; 1 h;
2: With ammonia in tetrahydrofuran
T=0°C; 0.166667 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/103755 A2, 2007 ;
Location in patent: Page/Page column 48; 56 ;
WO 2007/103755 A1
