3-(2-氯乙基)-2,4(1H,3H)-喹唑啉二酮合成路线 （共 22 条）
反应条件
sodium hydroxide in ethanol 0.0166667 h;
参考文献
Papadopoulos, Eleftherios Paul
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1553 - 1558
反应条件
1: 94 percent / acetonitrile / 2 h / Ambient temperature 2: 77 percent / conc. HCl / ethanol / 0.5 h / Heating View Scheme
参考文献
Chern, Ji-Wang; Shish, Fang-Jy; Chang, Chau-Dung; Chan, Chao-Han; Liu, Kang-Chien
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1103 - 1105
反应条件
1: chloroform / 50 °C 2: chloroform / 4 h / 150 °C 3: thionyl chloride / chloroform / 4 h / |Reflux View Scheme
参考文献
Fakhraian, Hossein; Heydary, Mehdi
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 151 - 156
反应条件
1: chloroform / 4 h / 150 °C 2: thionyl chloride / chloroform / 4 h / |Reflux View Scheme
参考文献
Fakhraian, Hossein; Heydary, Mehdi
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 151 - 156
反应条件
hydrogenchloride 1 h; steam bath;
参考文献
Papadopoulos, Eleftherios Paul
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1553 - 1558
反应条件
1: 10percent aq. KHCO3 / 0.07 h 2: 90 percent / 10percent aq. KHCO3 / 0.5 h / steam bath 3: 83 percent / conc. aq. HCl / 0.02 h / steam bath View Scheme
参考文献
Papadopoulos, Eleftherios Paul
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1553 - 1558
反应条件
1: sodium carbonate / butanone / 24 h / |Reflux 2: ethanol View Scheme
参考文献
Fakhraian, Hossein; Heydary, Mehdi
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 151 - 156
反应条件
sodium carbonate in water
参考文献
Janssen Pharmaceutica, N.V.
Patent: US4335127 A1, 1982 ;
反应条件
sodium carbonate in butanone 24 h; Reflux;
参考文献
Fakhraian, Hossein; Heydary, Mehdi
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 151 - 156
反应条件
1: 83 percent / 10percent aq. NaOH / 0.5 h
2: 90 percent / aq. HBr / 0.03 h / steam bath
View Scheme
参考文献
Papadopoulos, Eleftherios Paul
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1553 - 1558
