1: 5-bromo-3H-isobenzofuran-1-one; (4-fluoro-phenyl)-magnesium bromide in tetrahydrofuran; toluene T=20°C; 1.5 h; Heating / reflux; 2: 3-(N,N-dimethylamino)-propylmagnesium chloride in tetrahydrofuran; toluene T=20 - 30°C; 18 h; 3: With hydrogenchloride in tetrahydrofuran; water; toluene T=20°C; 1 h;

1: With phosphoric acid in water T=90°C; 1 h; Heating / reflux; 2: With ammonia in water; toluene T=10 - 25°C;