2-氯-4-甲基-烟酸乙酯合成路线 （共 10 条）
反应条件
1: 90 percent / NaOH / methanol; H2O / 75 °C 2: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h 3: NH3(g) / toluene / below 30 deg C 4: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme
参考文献
Zhang; Stout; Keay; Scriven; Toomey; Goe
Tetrahedron, 1995 , vol. 51, # 48 p. 13177 - 13184
反应条件
sodium hydroxide in methanol; water T=75°C;
参考文献
Zhang; Stout; Keay; Scriven; Toomey; Goe
Tetrahedron, 1995 , vol. 51, # 48 p. 13177 - 13184
反应条件
sodium hydroxide in methanol; water
参考文献
Reilly Industries, Inc.
Patent: US5493028 A1, 1996 ;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6136982 A1, 2000 ;
反应条件
1: 90 percent / NaOH / methanol; H2O / 75 °C 2: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h 3: NH3(g) / toluene / below 30 deg C View Scheme
参考文献
Zhang; Stout; Keay; Scriven; Toomey; Goe
Tetrahedron, 1995 , vol. 51, # 48 p. 13177 - 13184
反应条件
1: With hydrogenchloride in ethanol
T=0°C; 8.25 h; Reflux;
2: With triethylamine in water
pH=7;
参考文献
Nippon Zoki Pharmaceutical Co., Ltd.
Patent: EP2128136 A1, 2009 ;
Location in patent: Page/Page column 8 ;
EP 2128136 A1
反应条件
hydrogenchloride in ethanol
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6136982 A1, 2000 ;
反应条件
hydrogenchloride; phosphorus trichoride in N,N-dimethyl-formamide
1.) 85 deg C; 2.) 90 deg C;
参考文献
Zhang; Stout; Keay; Scriven; Toomey; Goe
Tetrahedron, 1995 , vol. 51, # 48 p. 13177 - 13184
反应条件
1: 34 percent / K2CO3 / ethyl acetate / 1.) 0 deg C; 2.) 25 deg C
2: 17 percent / PCl3, HCl(g) / dimethylformamide / 1.) 85 deg C; 2.) 90 deg C
View Scheme
参考文献
Zhang; Stout; Keay; Scriven; Toomey; Goe
Tetrahedron, 1995 , vol. 51, # 48 p. 13177 - 13184
反应条件
1: 90 percent / NaOH / methanol; H2O / 75 °C
2: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h
View Scheme
参考文献
Zhang; Stout; Keay; Scriven; Toomey; Goe
Tetrahedron, 1995 , vol. 51, # 48 p. 13177 - 13184
