(2E,6E,10E)-1-溴-3,7,11,15-四甲基-2,6,10,14-十六碳四烯合成路线 （共 35 条）
反应条件
1: 1.) n-BuLi / 1.) THF, HMPA, hexane, -78 deg C, 1.5 h, 2.) 6 h
2: 5percent sodium amalgam, disodium hydrogen phosphate / methanol / 2 h / 0 °C
3: 91 percent / PBr3, pyridine / diethyl ether / 6 h / -5 °C
View Scheme
参考文献
Sato, Kikumasa; Inoue, Seiichi; Onishi, Akira; Uchida, Nobuhiko; Minowa, Nobuto
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 761 - 769
反应条件
1: 5percent sodium amalgam, disodium hydrogen phosphate / methanol / 2 h / 0 °C
2: 91 percent / PBr3, pyridine / diethyl ether / 6 h / -5 °C
View Scheme
参考文献
Sato, Kikumasa; Inoue, Seiichi; Onishi, Akira; Uchida, Nobuhiko; Minowa, Nobuto
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 761 - 769
反应条件
1: sodium / ethanol
2: 131 mg / sodium hydride / 1,2-dimethoxy-ethane / 48 h
3: 1.68 g / lithium aluminium hydride / diethyl ether / 2 h / Heating
4: phosphorus tribromide
5: sodium / ethanol
6: 288 mg
7: lithium aluminium hydride
8: phosphorus tribromide
View Scheme
参考文献
Suga, Takayuki; Shishibori, Tsuyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2098 - 2104
反应条件
1: 33.6 g / phosphorus tribromide / diethyl ether / 4 h
2: sodium / ethanol
3: 131 mg / sodium hydride / 1,2-dimethoxy-ethane / 48 h
4: 1.68 g / lithium aluminium hydride / diethyl ether / 2 h / Heating
5: phosphorus tribromide
6: sodium / ethanol
7: 288 mg
8: lithium aluminium hydride
9: phosphorus tribromide
View Scheme
参考文献
Suga, Takayuki; Shishibori, Tsuyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2098 - 2104
反应条件
1: 1.68 g / lithium aluminium hydride / diethyl ether / 2 h / Heating
2: phosphorus tribromide
3: sodium / ethanol
4: 288 mg
5: lithium aluminium hydride
6: phosphorus tribromide
View Scheme
参考文献
Suga, Takayuki; Shishibori, Tsuyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2098 - 2104
反应条件
1: 131 mg / sodium hydride / 1,2-dimethoxy-ethane / 48 h
2: 1.68 g / lithium aluminium hydride / diethyl ether / 2 h / Heating
3: phosphorus tribromide
4: sodium / ethanol
5: 288 mg
6: lithium aluminium hydride
7: phosphorus tribromide
View Scheme
参考文献
Suga, Takayuki; Shishibori, Tsuyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2098 - 2104
反应条件
1: 264 mg / Li, ethylamine / diethyl ether / 1 h / -78 °C
2: 91 percent / PBr3, pyridine / diethyl ether / 6 h / -5 °C
View Scheme
参考文献
Sato, Kikumasa; Inoue, Seiichi; Onishi, Akira; Uchida, Nobuhiko; Minowa, Nobuto
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 761 - 769
反应条件
1: ethanol; palladium-calcium carbonate / partielle Hydrierung
2: pyridine; PBr3 / -15 °C
View Scheme
参考文献
Ruzicka; Firmenich
Helvetica Chimica Acta, 1939 , vol. 22, p. 395
反应条件
1: pyridine; phosphorus tribromoide / -15 °C
2: ethanol; petroleum ether / beim Spalten des nicht naeher beschriebenen Farnesylacetessigesters mit methylalkoh. KOH
3: potassium tert-butylate; diethyl ether / -20 °C
4: ethanol; palladium-calcium carbonate / partielle Hydrierung
5: pyridine; PBr3 / -15 °C
View Scheme
参考文献
Ruzicka; Firmenich
Helvetica Chimica Acta, 1939 , vol. 22, p. 395
反应条件
1: potassium tert-butylate; diethyl ether / -20 °C
2: ethanol; palladium-calcium carbonate / partielle Hydrierung
3: pyridine; PBr3 / -15 °C
View Scheme
参考文献
Ruzicka; Firmenich
Helvetica Chimica Acta, 1939 , vol. 22, p. 395
