1-苄基-3,5-哌啶二酮合成路线 （共 12 条）
反应条件
Candida antarctica lipase B in isopropyl alcohol T=20°C; 16 h;
参考文献
Olofsson, Berit; Bogar, Krisztian; Fransson, Ann-Britt L.; Baeckvall, Jan-E.
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8256 - 8260
反应条件
1: potassium tert-butoxide / tetrahydrofuran / 18 h / 0 - 20 °C 2: tetrahydrofuran / 1 h / 0 °C 3: Candida antarctica lipase B / propan-2-ol / 16 h / 20 °C View Scheme
参考文献
Huynh, Tri H. V.; Shim, Irene; Bohr, Henrik; Abrahamsen, Bjarke; Nielsen, Birgitte; Jensen, Anders A.; Bunch, Lennart
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5403 - 5412
反应条件
1: 79 percent / NaHCO3 / ethanol / 16 h / 60 °C 2: potassium tert-butoxide / tetrahydrofuran / 18 h / 0 - 20 °C 3: tetrahydrofuran / 1 h / 0 °C 4: Candida antarctica lipase B / propan-2-ol / 16 h / 20 °C View Scheme
参考文献
Huynh, Tri H. V.; Shim, Irene; Bohr, Henrik; Abrahamsen, Bjarke; Nielsen, Birgitte; Jensen, Anders A.; Bunch, Lennart
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5403 - 5412
反应条件
1: tetrahydrofuran / 1 h / 0 °C 2: Candida antarctica lipase B / propan-2-ol / 16 h / 20 °C View Scheme
参考文献
Olofsson, Berit; Bogar, Krisztian; Fransson, Ann-Britt L.; Baeckvall, Jan-E.
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8256 - 8260
反应条件
1: tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere 2: sodium hydrogencarbonate / ethanol / 18 h / 60 °C / Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere View Scheme
参考文献
Huynh, Tri H. V.; Shim, Irene; Bohr, Henrik; Abrahamsen, Bjarke; Nielsen, Birgitte; Jensen, Anders A.; Bunch, Lennart
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5403 - 5412
反应条件
1: 70 percent / NH2OH*HCl 2: pyridine 3: 75 percent 4: 73 percent / H2 / 5percent Pd/C / 3040 Torr / Ambient temperature 5: 67 percent / aq. NaOH / 1 h / 65 °C View Scheme
参考文献
Tamura, Yasumitsu; Fujita, Masanobu; Chen, Ling Ching; Kiyokawa, Hiroshi; Ueno, Kyoji; Kita, Yasuyuki
Heterocycles, 1981 , vol. 15, # 2 p. 871 - 874
反应条件
1: 1.) trifluoroacetic acid, N-chlorosuccinimide, dimethyl sulphide / 1.) CH2Cl2, -20 deg C, 2.) CH2Cl2, RT, 3 h 2: 1.) NaH, 2.) CuI / 1.) HMPA, RT, 30 min, 2.) HMPA, 120 deg C, 2 h View Scheme
参考文献
Yang, Shyh-Chyun; Wang, Huey-Min; Kuo, Ching-Shwu; Chen, Ling-Ching
Heterocycles, 1991 , vol. 32, # 12 p. 2399 - 2405
反应条件
1: 67 percent / HCl 2: 96 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h 3: 84 percent / H2 / Pd/C / methanol / Ambient temperature View Scheme
参考文献
Chen, Ling-Ching; Yang, Shyh-Chyun
Heterocycles, 1986 , vol. 24, # 12 p. 3411 - 3415
反应条件
1: 95 percent / triethylamine / CHCl3 / 2 h / Ambient temperature
2: 70 percent / 10 percent HCl / acetonitrile / 2 h / 80 °C
View Scheme
参考文献
Tamura; Chen; Fujita; Kita
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 1 p. 1 - 4
反应条件
1: 67 percent / HCl(g)
2: benzene / 2 h / Heating
3: 73 percent / NaBH4 / ethanol / Ambient temperature
View Scheme
参考文献
Chen Ling-Ching; Wang, Eng-Chi; Lin, Jen-Hom; Wu, Shihn-Sheng
Heterocycles, 1984 , vol. 22, # 12 p. 2769 - 2773
