反应条件
1.1: 80 percent / tetrahydrofuran / 24 h / Heating 2.1: n-BuLi / tetrahydrofuran / -40 - -10 °C 2.2: 80 percent / tetrahydrofuran 3.1: 78 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; diisopropylethylamine / dimethylformamide / 48 h / 20 °C 4.1: 82 percent / aq. AcOH; NaNO2 / 95 °C View Scheme
参考文献
Wrobleski, Stephen T.; Chen, Ping; Hynes Jr., John; Lin, Shuqun; Norris, Derek J.; Pandit, Chennagiri R.; Spergel, Steven; Wu, Hong; Tokarski, John S.; Chen, Xiaorong; Gillooly, Kathleen M.; Kiener, Peter A.; McIntyre, Kim W.; Patil-Koota, Vina; Shuster, David J.; Turk, Lori A.; Yang, Guchen; Leftheris, Katerina
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2110 - 2116
