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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
50874-07-2
合成路线
（共 10 条）
19213-72-0
1-乙氧甲酰咪唑
+
35553-92-5
3-甲氧基苯基乙酸乙酯
→
反应条件
50874-07-2
反应条件
1: ethyl 3'-methoxyphenylacetate With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.5 h; 2: 1-ethoxycarbonyl-imidazole in tetrahydrofuran T=-78 - 20°C;
参考文献
Behera, Manoranjan; Venkat Ragavan; Sambaiah; Erugu, Balaiah; Rama Krishna Reddy; Mukkanti; Yennam, Satyanarayana
Tetrahedron Letters, 2012 , vol. 53, # 9 p. 1060 - 1062
766-85-8
3-碘苯甲醚
+
105-53-3
丙二酸二乙酯
→
反应条件
50874-07-2
反应条件
copper(l) iodide; caesium carbonate; L-proline in dimethyl sulfoxide T=40°C; 12 h;
参考文献
Xie, Xiaoan; Cai, Guorong; Ma, Dawei
Organic Letters, 2005 , vol. 7, # 21 p. 4693 - 4695
2398-37-0
间溴苯甲醚
+
105-53-3
丙二酸二乙酯
→
反应条件
50874-07-2
反应条件
copper(l) iodide; caesium carbonate; L-proline in dimethyl sulfoxide T=50°C; 36 h;
参考文献
Xie, Xiaoan; Cai, Guorong; Ma, Dawei
Organic Letters, 2005 , vol. 7, # 21 p. 4693 - 4695
35553-92-5
3-甲氧基苯基乙酸乙酯
+
623-49-4
氰基甲酸乙酯
→
反应条件
50874-07-2
反应条件
1: ethyl 3'-methoxyphenylacetate With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere; 2: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran T=-78 - 20°C; Inert atmosphere;
参考文献
Rios-Lombardia, Nicolas; Busto, Eduardo; Garcia-Urdiales, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2571 - 2574
83026-36-2
→
反应条件
50874-07-2
反应条件
sodium α-(dimethylamino)naphthalenide in N,N,N',N',N'',N''-hexamethylphosphoric triamide; benzene 0.00833333 h;
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
35553-92-5
3-甲氧基苯基乙酸乙酯
+
105-58-8
碳酸二乙酯
→
反应条件
50874-07-2
反应条件
sodium hydride Ambient temperature;
参考文献
Richon, Allen B.; Maragoudakis, Michael E.; Wasvary, James S.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 745 - 747
2398-37-0
间溴苯甲醚
→
反应条件
50874-07-2
反应条件
1: 1.) Mg / 1.) THF, 2a.) ether, -78 deg C, 2b.) 20 deg C, 1.5 h 2: 86 percent / Et3N, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h / 20 °C 3: 78 percent / sodium α-(dimethylamino)naphthalenide / hexamethylphosphoric acid triamide; benzene / 0.01 h View Scheme
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
83026-22-6
→
反应条件
50874-07-2
反应条件
1: 86 percent / Et3N, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h / 20 °C 2: 78 percent / sodium α-(dimethylamino)naphthalenide / hexamethylphosphoric acid triamide; benzene / 0.01 h View Scheme
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
609-09-6
酮基丙二酸二乙酯
→
反应条件
50874-07-2
反应条件
1: 1.) Mg / 1.) THF, 2a.) ether, -78 deg C, 2b.) 20 deg C, 1.5 h 2: 86 percent / Et3N, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h / 20 °C 3: 78 percent / sodium α-(dimethylamino)naphthalenide / hexamethylphosphoric acid triamide; benzene / 0.01 h View Scheme
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
50874-07-2
→
反应条件
427-17-8
3-羟基苯巴比妥
反应条件
1: sodium ethylate 3: aqueous HBr View Scheme
参考文献
Tsukamoto et al.
Pharmaceutical Bulletin, 1955 , vol. 3, p. 239,241
