1-苄基-4-碘-1H-吡唑合成路线 （共 10 条）
反应条件
potassium carbonate in acetone 3 h; Heating / reflux;
参考文献
ILIAD CHEMICALS PTY LTD
Patent: WO2006/84338 A1, 2006 ;
Location in patent: Page/Page column 63 ;
反应条件
ammonium cerium(IV) nitrate; iodine in acetonitrile T=20°C; 4 h;
参考文献
Rodriguez-Franco, Maria Isabel; Dorronsoro, Isabel; Hernandez-Higueras, Ana I; Antequera, Gema
Tetrahedron Letters, 2001 , vol. 42, # 5 p. 863 - 865
反应条件
boron trifluoride diethyl etherate in dichloromethane; acetonitrile T=-50 - 50°C; Claisen Rearrangement; 1 h;
参考文献
Nguyen, Hai; Khatri, Hem Raj; Zhu, Jianglong
Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5464 - 5466
反应条件
in N,N-dimethyl-formamide; mineral oil
参考文献
CV Therapeutics, Inc.
Patent: US6214807 B1, 2001 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Palle, Venkata P.; Elzein, Elfatih O.; Gothe, Scott A.; Li, Zhihe; Gao, Zhenhai; Meyer, Stephanie; Blackburn, Brent; Zablocki, Jeff A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2935 - 2939
反应条件
sodium ethanolate 1.) C2H5OH, 30 min, 2.) C2H5OH, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Holzer, Wolfgang; Poecher, Ingrid
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 189 - 194
反应条件
nitric acid in tetrahydrofuran T=20°C; 2.5 h;
参考文献
Synthetic Communications, , vol. 42, # 23 p. 3463 - 3471
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) chloroform complex in N,N-dimethyl-formamide T=85°C;
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
Location in patent: Page/Page column 57 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); triethylamine in 1,4-dioxane T=80°C; Masuda borylation; 4 h; Inert atmosphere;
参考文献
Merkul, Eugen; Schaefer, Elisabeth; Mueller, Thomas J. J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3139 - 3141
反应条件
1: N-Bn-4-iodo-1H-pyrazole With isopropylmagnesium chloride in tetrahydrofuran; diethyl ether T=0°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; diethyl ether T=20°C; 1 h;
参考文献
Usami, Yoshihide; Watanabe, Ryo; Fujino, Yuiko; Shibano, Makio; Ishida, Chihiro; Yoneyama, Hiroki; Harusawa, Shinya; Ichikawa, Hayato
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 12 p. 1550 - 1560
