4-溴-N,N-双(三甲基甲硅烷基)苯胺合成路线 （共 18 条）
反应条件
1: 4-bromo-aniline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphereSchlenk technique; 2: chloro-trimethyl-silane in tetrahydrofuran; hexane T=-78 - 20°C; 6 h; Inert atmosphereSchlenk technique;
参考文献
Sudhakar, Pagidi; Mukherjee, Sanjoy; Thilagar, Pakkirisamy
Organometallics, 2013 , vol. 32, # 10 p. 3129 - 3133
反应条件
1: triethylamine 2: 91 percent / methyl iodide / hexane / 10 h / 80 °C View Scheme
参考文献
Weisenfeld, Robert B.
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2434 - 2436
反应条件
triethylamine 8 h; Heating / reflux;
参考文献
Clariant GmbH
Patent: EP1479686 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
methyl iodide in hexane T=80°C; 10 h;
参考文献
Hamada, Yoshitaka; Yamamoto, Yasushi; Shimizu, Hideaki
Journal of Organometallic Chemistry, 1996 , vol. 510, # 1-2 p. 1 - 6
反应条件
triethylamine T=80°C; 7 h;
参考文献
Schorr, Manfred; Schmitt, Wilfried
Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 68, # 1-4 p. 25 - 36
反应条件
methyl-magnesium chloride 1.) 0 deg C, 2.) THF, 25 deg C; Yield given. Multistep reaction;
参考文献
Weisenfeld, Robert B.
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2434 - 2436
反应条件
n-butyllithium; naphthalenyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 8 h, 2.) -78 deg C, 1 h; -78 deg C to r.t., overnight;
参考文献
Barluenga, Jose; Montserrat, Javier M.; Florez, Josefa
Journal of Organic Chemistry, 1993 , vol. 58, # 22 p. 5976 - 5980
反应条件
2: 1N HCl View Scheme
参考文献
Barluenga, Jose; Montserrat, Javier M.; Florez, Josefa
Tetrahedron Letters, 1992 , vol. 33, # 41 p. 6183 - 6186
反应条件
potassium methanolate in tetrahydrofuran T=0 - 20°C; 12 h;
参考文献
Helvetica Chimica Acta, , vol. 86, # 9 p. 3096 - 3117
反应条件
potassium methanolate in tetrahydrofuran T=0 - 20°C; 12 h;
参考文献
Helvetica Chimica Acta, , vol. 86, # 9 p. 3096 - 3117
