4-溴-N,N-双(三甲基甲硅烷基)苯胺合成路线 （共 18 条）
反应条件
tetrabutyl ammonium fluoride; silica gel in tetrahydrofuran T=-70 - 20°C; 12 h;
参考文献
Helvetica Chimica Acta, , vol. 86, # 9 p. 3096 - 3117
参考文献
Cho, Bongsup P.; Yang, Tianle; Blankenship, Lonnie R.; Moody, Joanna D.; Churchwell, Mona; Beland, Frederick A.; Culp, Sandra J.
Chemical Research in Toxicology, 2003 , vol. 16, # 3 p. 285 - 294
反应条件
1: 4-bromo-N,N-bis(trimethylylsilyl)aniline With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere; 2: tri-isopropoxy-borane in tetrahydrofuran T=-78 - 25°C; 4.5 h; Inert atmosphere; 3: With 2,3-dimethylbutane-2,3-diol; acetic acid in tetrahydrofuran T=20°C; pH=5; 0.75 h; Inert atmosphere;
参考文献
Medicinal Chemistry Research, , vol. 22, # 1 p. 367 - 381
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane 1.5 h; Heating;
参考文献
Herbert, John M.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 817 - 819
反应条件
1: 1.) Mg, I2 / 1.) THF, RT, 20 min, 2.) THF, RT, overnight
2: 82 percent / triethylamine / 1.5 h / Ambient temperature
3: 91 percent / H2O / acetone / 48 h / 80 °C
4: 91 percent / 1.0 M aq. tetrabutylammonium hydroxide (TBAH) / acetonitrile / 48 h / Ambient temperature
View Scheme
参考文献
Weisenfeld, Robert B.
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2434 - 2436
反应条件
Yield given. Multistep reaction;
参考文献
Hellwinkel, Dieter; Fritsch, Helmut
Chemische Berichte, 1990 , vol. 123, # 11 p. 2207 - 2226
反应条件
potassium methanolate in tetrahydrofuran
T=0 - 20°C; 12 h;
参考文献
Denonne, Frederic; Seiler, Paul; Diederich, Francois
Helvetica Chimica Acta, 2003 , vol. 86, # 9 p. 3096 - 3117
反应条件
tetrabutyl ammonium fluoride; silica gel in tetrahydrofuran
T=-70 - 20°C; 12 h;
参考文献
Denonne, Frederic; Seiler, Paul; Diederich, Francois
Helvetica Chimica Acta, 2003 , vol. 86, # 9 p. 3096 - 3117
