4-(4-硝基苯甲酰)四氢-1(2H)-吡嗪羧酸叔丁酯合成路线 （共 3 条）
反应条件
4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 5 h;
参考文献
WO2008/139161 A1, ;
Page/Page column 161 ;
WO 2008/139161 A1
反应条件
triethylamine in DMF (N,N-dimethyl-formamide)
参考文献
EP1518855 A1, ;
Page/Page column 22 ;
EP 1518855 A1
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=760.051 Torr; 18 h;
参考文献
CATABASIS PHARMACEUTICALS, INC.; MILNE, Jill C.; JIROUSEK, Michael R.; VU, Chi B.
Patent: WO2013/177536 A2, 2013 ;
Location in patent: Paragraph 0260 ;
