4-溴-2-三氟甲基苯甲酸合成路线 (共 4 条)
反应条件
triethylamine in dichloromethane T=20°C; 0.25 h;
参考文献
WO2007/40440 A1, ;
Page/Page column 115-116 ;
WO 2007/040440 A1
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=120°C; 0.166667 h; Microwave irradiation; 2: With hydrogenchloride; water in tetrahydrofuran; dichloromethane pH=1;
参考文献
WO2007/40440 A1, ;
Page/Page column 135 ;
WO 2007/040440 A1
反应条件
1: 4-bromo-2-(trifluoro-methoxy)iodobenzene With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C; Inert atmosphere;
参考文献
ACS Medicinal Chemistry Letters, , vol. 4, # 11 p. 1064 - 1068
反应条件
hydrogenchloride Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28952 A1, 2012 ;
Location in patent: Page/Page column 19 ;