4-(2-甲氧基乙基)-1-哌啶羧酸 1,1-二甲基乙酯合成路线 （共 3 条）
反应条件
hydrogenchloride in diethyl ether; dichloromethane
参考文献
Kelly, Nicholas Michael; Koch, Kristian Norup; Tolf, Bo-Ragnar
Patent: US2004/67931 A1, 2004 ;
Location in patent: Page/Page column 36-37 ;
反应条件
1: 4-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester With sodium hydride in tetrahydrofuran
T=0°C; 0.5 h;
2: methyl iodide in tetrahydrofuran
22 h;
参考文献
PIRAMED LIMITED
Patent: WO2006/46031 A1, 2006 ;
Location in patent: Page/Page column 78 ;
WO 2006/046031 A1
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane
21 h;
参考文献
PIRAMED LIMITED
Patent: WO2007/122410 A1, 2007 ;
Location in patent: Page/Page column 81 ;
