1-(4-氯苯基)-1-环丁羧酸合成路线 （共 7 条）
反应条件
potassium hydroxide in diethylene glycol
参考文献
Hill, E. Alexander; Li, Baoju
Journal of Organometallic Chemistry, 1993 , vol. 448, # 1-2 p. 9 - 14
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethylene glycol
参考文献
Commonwealth Scientific and Industrial Research Organization
Patent: US4235926 A1, 1980 ;
反应条件
1: 61 percent / NaH / dimethylsulfoxide 2: 73 percent / KOH / bis-(2-hydroxy-ethyl) ether View Scheme
参考文献
Hill, E. Alexander; Li, Baoju
Journal of Organometallic Chemistry, 1993 , vol. 448, # 1-2 p. 9 - 14
反应条件
sodium azide; tetrabutylammomium bromide; zinc trifluoromethanesulfonate in tetrahydrofuran T=60°C; 18 h;
参考文献
US2008/161317 A1, ;
Page/Page column 30 ;
反应条件
ammonium formate; 5-palladium/activated carbon in water; isopropyl alcohol T=65°C; 5 h;
参考文献
Harris, Neil Victor; Fenton, Garry
Patent: US2004/6056 A1, 2004 ;
Location in patent: Page 39 ;
反应条件
thionyl chloride
T=20°C; 1 h;
参考文献
WYETH
Patent: WO2008/73936 A1, 2008 ;
Location in patent: Page/Page column 126 ;
WO 2008/073936 A1
反应条件
sulfuric acid
Heating / reflux;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V
Patent: WO2003/103604 A2, 2003 ;
Location in patent: Page 62-63 ;
WO 03/103604 A2
