4-溴-2,6-二甲基吡啶合成路线 （共 8 条）
反应条件
copper(I) bromide Diazotization;
参考文献
Roczniki Chemii, , vol. 33, p. 387,392
Chem.Abstr., , p. 18954
反应条件
phosphorus pentabromide; phosphorus oxytribromide in chloroform T=80 - 110°C; 5 h;
参考文献
Takalo, Harri; Pasanen, Paavo; Kankare, Jouko
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 6 p. 373 - 377
反应条件
copper(ll) bromide in methanol T=80°C;
参考文献
Murphy, Jaclyn M.; Liao, Xuebin; Hartwig, John F.
Journal of the American Chemical Society, 2007 , vol. 129, # 50 p. 15434 - 15435
反应条件
1: 85 percent / conc. aq. ammonia / 10 h / 120 - 130 °C 2: 65 percent / PBr5, POBr3 / CHCl3 / 5 h / 80 - 110 °C View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 42, # 6 p. 373 - 377
反应条件
tetrakis(triphenylphosphine) palladium(0); zinc 1.) THF, r.t., 1.5 h, 2.) THF, r.t., 45 h; Yield given. Multistep reaction;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Murata, Naoko; Yamanaka, Hiroshi
Tetrahedron, 1993 , vol. 49, # 43 p. 9713 - 9720
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexanes; toluene T=-40°C; 0.666667 h; 2: With hydrogenchloride; water in tetrahydrofuran; hexanes; toluene T=-20 - 20°C;
参考文献
ACHILLION PHARMACEUTICALS, INC.
Patent: WO2005/19228 A1, 2005 ;
Location in patent: Page/Page column 62-64 ;
反应条件
tetraethylammonium iodide; zinc; NiBr2(PPh3)2 in tetrahydrofuran
18 h; Heating;
参考文献
Yoshizawa, Michito; Nakagawa, Junichi; Kumazawa, Kazuhisa; Nagao, Muneki; Kawano, Masaki; Ozeki, Tomoji; Fujita, Makoto
Angewandte Chemie - International Edition, 2005 , vol. 44, # 12 p. 1810 - 1813
反应条件
1: 84 percent / bis<triphenylphosphine>palladium dichloride, copper(I) iodide, triethylamine / 5 h / 80 °C
2: 62 percent / aq. KOH / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Sakamoto, Takao; Shiraiwa, Masafumi; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1983 , # 4 p. 312 - 314
