N-(2-氯苯基)-2-氰基乙酰胺合成路线 （共 4 条）
反应条件
1: anhydrous cyanoacetic acid With phosphorus pentachloride in dichloromethane
0.5 h; Reflux;
2: 2-chloro-aniline in dichloromethane
2 h; Reflux;
参考文献
Hazeldine, Stuart; Pachaiyappan, Boobalan; Steinbergs, Nora; Nowotarski, Shannon; Hanson, Allison S.; Casero, Robert A.; Woster, Patrick M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7378 - 7391
参考文献
Piccinini; Delpiano
Chem. Zentralbl., 1907 , vol. 78, # I p. 336
参考文献
Gazit, Aviv; Osherov, Nir; Posner, Israel; Yaish, Pnina; Poradosu, Enrique; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1896 - 1907
反应条件
potassium permanganate; water
T=70 - 80°C;
参考文献
Piccinini; Delpiano
Chemisches Zentralblatt, 1907 , p. I,336
