7-(二乙基氨基)香豆素-3-羧酸合成路线 （共 15 条）
反应条件
sodium hydroxide in methanol
参考文献
Wells, Geoffrey; Suggitt, Marie; Coffils, Marissa; Baig, Mirza A.H.; Howard, Philip W.; Loadman, Paul M.; Hartley, John A.; Jenkins, Terence C.; Thurston, David E.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 2147 - 2151
反应条件
zirconium(IV) dichloride oxide octahydrate in water Sonication;
参考文献
Maldonado-Dominguez, Mauricio; Arcos-Ramos, Rafael; Romero, Margarita; Flores-Perez, Blas; Farfan, Norberto; Santillan, Rosa; Lacroix, Pascal G.; Malfant, Isabelle
New Journal of Chemistry, 2014 , vol. 38, # 1 p. 260 - 268
反应条件
1: With piperidine in ethanol 6 h; Reflux; 2: With sodium hydroxide in ethanol 0.25 h; Reflux; 3: With hydrogenchloride in ethanol; water pH=2;
参考文献
Yin, Qin; Huang, Chusen; Zhang, Chao; Zhu, Weiping; Xu, Yufang; Qian, Xuhong; Yang, Yi
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 43 p. 7566 - 7573
反应条件
1: With sodium hydroxide; water 2: With hydrogenchloride in water
参考文献
Chen, Kuan-Hung; Liao, Jen-Hai; Chan, Hsin-Yu; Fang, Jim-Min
Journal of Organic Chemistry, 2009 , vol. 74, # 2 p. 895 - 898
参考文献
Brunet, Ernesto; Garcia-Losada, Pablo; Rodriguez-Ubis, Juan-Carlos; Juanes, Olga
Canadian Journal of Chemistry, 2002 , vol. 80, # 2 p. 169 - 174
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Tkach, I. I.; Reznichenko, A. V.; Luk'yanets, E. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 8 p. 872 - 880
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 8 p. 1043 - 1052
反应条件
piperidine; acetic acid in ethanol T=0°C; 5 h; Reflux;
参考文献
Gustafson, Tiffany P.; Cao, Qian; Wang, Steven T.; Berezin, Mikhail Y.
Chemical Communications, 2013 , vol. 49, # 7 p. 680 - 682
反应条件
1: 84 percent / aq. 15percent HCl / ethanol / 0.33 h / Heating 2: 82 percent / 90percent H2SO4 / 0.33 h / 90 - 95 °C 3: 75 percent / aq. 20percent HCl / 2 h / Heating View Scheme
参考文献
Tkach, I. I.; Reznichenko, A. V.; Luk'yanets, E. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 8 p. 872 - 880
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 8 p. 1043 - 1052
反应条件
sulfuric acid; water 1) frrom 90 deg C to 95 deg C, 40 min, 2.) reflux, 40 min; Yield given. Multistep reaction;
参考文献
Tkach, I. I.; Reznichenko, A. V.; Luk'yanets, E. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 8 p. 872 - 880
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 8 p. 1043 - 1052
反应条件
1: 22 percent / acetic acid / 1 h 2: 82 percent / 90percent H2SO4 / 0.33 h / 90 - 95 °C 3: 75 percent / aq. 20percent HCl / 2 h / Heating View Scheme
参考文献
Tkach, I. I.; Reznichenko, A. V.; Luk'yanets, E. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 8 p. 872 - 880
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 8 p. 1043 - 1052
