反应条件
1: 98 percent / NaHCO3 / H2O; toluene / 16 h / Ambient temperature 2: Jones reagent / acetone / 2.25 h / Ambient temperature 3: NaBH4 / methanol; H2O / 20 h / -5 °C 4: 83 percent / p-toluenesulfonic acid / 36 h / Heating 5: 80 percent / pyridine / CHCl3 / 168 h / Ambient temperature 6: 70 percent / dimethylsulfoxide / 3 h / 80 °C 7: 94 percent / HCl / 96 h 8: 100 percent / 4 M NaOH / tetrahydrofuran; H2O / 0.92 h 9: 75 percent / H2 / 10percent Pd/C / methanol / 0.5 h / 2482.3 - 2585.7 Torr View Scheme
参考文献
Bridges, Richard J.; Stanley, Mark S.; Anderson, Michael W.; Cotman, Carl W.; Chamberlin, A. Richard
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 717 - 725
