反应条件
1: 2 N NaOH / toluene; H2O / 2 h / 5 - 10 °C
2: 13 percent / NaHCO3 / ethanol / 16 h / Heating
3: 1.) NaH, 2.) Me3N*SO3 / DMF, 1.) 30 min, room temp., 2.) 30 min
4: H2 / 10 percent Pd/C / ethanol / 0.5 h / 2280.2 - 3037.7 Torr
View Scheme
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
