hydrogenchloride in tetrahydrofuran; water
0.25 h; Ambient temperaturesimilar further reactions of other related amidines (various reaction-times and amounts of solvent); Product distribution;
参考文献
Ono; Tamura
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 3 p. 590 - 596
Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Boden, Neville; Bushby, Richard J.; Clark, Leslie D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 543 - 551
1: water / 6.67 h / 275 °C / |Inert atmosphere
2: water / 150 °C / |Green chemistry
View Scheme
参考文献
Medina-Ramos, Wilmarie; Mojica, Mike A.; Cope, Elizabeth D.; Hart, Ryan J.; Pollet, Pamela; Eckert, Charles A.; Liotta, Charles L.
Green Chemistry, 2014 , vol. 16, # 4 p. 2147 - 2155