19-羟基-4-雄甾烯-3,17-二酮合成路线 （共 36 条）
反应条件
1: 2.1 g / KOH / methanol; tetrahydrofuran / 1.5 h / 16 °C 2: 5.8 g / Jones' reagent / acetone / 0.25 h 3: 4.02 g / NaHCO3 / pyridine; H2O / 2.5 h / 100 °C 4: 3.3 g / Zn / acetic acid / 0.75 h / 90 °C View Scheme
参考文献
Joska; Fajkos
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2423 - 2423
反应条件
1: 4.02 g / NaHCO3 / pyridine; H2O / 2.5 h / 100 °C 2: 3.3 g / Zn / acetic acid / 0.75 h / 90 °C View Scheme
参考文献
Joska; Fajkos
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2423 - 2423
反应条件
1: 1.8 g / pyridine / 24 h / Ambient temperature 2: 2.1 g / KOH / methanol; tetrahydrofuran / 1.5 h / 16 °C 3: 5.8 g / Jones' reagent / acetone / 0.25 h 4: 4.02 g / NaHCO3 / pyridine; H2O / 2.5 h / 100 °C 5: 3.3 g / Zn / acetic acid / 0.75 h / 90 °C View Scheme
参考文献
Joska; Fajkos
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2423 - 2423
反应条件
1: peroxybenzoic acid / anschliessende Hydrolyse 2: anschliessend mit Carbazoylmethyl-trimethyl-ammonium-chlorid View Scheme
参考文献
Ehrenstein; Duennenberger
Journal of Organic Chemistry, 1956 , vol. 21, p. 783,789
反应条件
1: benzene 2: (i) HCO2H, (ii) Al(OiPr)3 View Scheme
参考文献
Sollman,P.B.
Journal of Organic Chemistry, 1963 , vol. 28, p. 3559 - 3562
参考文献
Nishikawa; Hagiwara
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 226
参考文献
Searle and Co.
Patent: US2819276 , 1956 ;
反应条件
sulfuric acid; triphenylmethane tetrafluoroborate 1.) CH2Cl2, 12h; 2.) ethanol, benzene, reflux, 4h; Yield given. Multistep reaction;
参考文献
Holland; Taylor
Canadian Journal of Chemistry, 1981 , vol. 59, # 19 p. 2809 - 2819
反应条件
(i) HCO2H, (ii) Al(OiPr)3; Multistep reaction;
参考文献
Sollman,P.B.
Journal of Organic Chemistry, 1963 , vol. 28, p. 3559 - 3562
反应条件
anschliessend mit Carbazoylmethyl-trimethyl-ammonium-chlorid;
参考文献
Ehrenstein; Duennenberger
Journal of Organic Chemistry, 1956 , vol. 21, p. 783,789
