3,4-二氢化-8-甲基-1(2H)-萘酮合成路线 （共 10 条）
反应条件
hydrogen; palladium 10 on activated carbon
T=20°C; 18 h;
参考文献
ALLERGAN, INC.
Patent: WO2003/99795 A1, 2003 ;
Location in patent: Page 73, 74 ;
WO 03/099795 A1
反应条件
BaMnO4 in dichloromethane
T=20°C; Oxidation; 6 h;
参考文献
Banerjee, Ajoy K.; Azocar, Jose A.; Vera, William
Synthetic Communications, 1999 , vol. 29, # 17 p. 2995 - 3001
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
10 h; Heating;
参考文献
Liu, Hsing-Jang; Ngooi, Teng Ko; Browne, Eric N. C.
Canadian Journal of Chemistry, 1988 , vol. 66, p. 3143 - 3152
反应条件
pyridine; chromium(VI) oxide in dichloromethane
参考文献
Demole,E.; Enggist,P.
Helvetica Chimica Acta, 1978 , vol. 61, p. 1335 - 1341
反应条件
1: 238 mg / LiAlH4 / tetrahydrofuran / 4 h / Heating
2: 90 percent / barium manganate / CH2Cl2 / 6 h / 20 °C
View Scheme
参考文献
Banerjee, Ajoy K.; Azocar, Jose A.; Vera, William
Synthetic Communications, 1999 , vol. 29, # 17 p. 2995 - 3001
反应条件
1: 40 percent / thionyl chloride / pyridine / 18 h / 20 °C
2: 238 mg / LiAlH4 / tetrahydrofuran / 4 h / Heating
3: 90 percent / barium manganate / CH2Cl2 / 6 h / 20 °C
View Scheme
参考文献
Banerjee, Ajoy K.; Azocar, Jose A.; Vera, William
Synthetic Communications, 1999 , vol. 29, # 17 p. 2995 - 3001
反应条件
1: 82 percent / LiI*2H2O, 2,4,6-collidine / 1.5 h / Heating
2: 58 percent / benzoyl peroxide, N-bromosuccinimide / CCl4 / 10 h / Heating
View Scheme
参考文献
Liu, Hsing-Jang; Ngooi, Teng Ko; Browne, Eric N. C.
Canadian Journal of Chemistry, 1988 , vol. 66, p. 3143 - 3152
反应条件
chromium(VI) oxide; water; acetic acid
参考文献
Boberg, Friedrich; Jachiewicz, Adam; Garming, Alfons
Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 72, # 1-4 p. 1 - 12
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine
1.) light petroleum, hexanes, 60 deg C, 2 h; Yield given. Multistep reaction;
参考文献
McCague
Tetrahedron Asymmetry, 1990 , vol. 1, # 2 p. 97 - 110
反应条件
1: (i) NaH, (ii) /BRN= 1209232/, Et3N
2: TiCl4 / acetone; CH2Cl2
3: AcOH
View Scheme
参考文献
Demole,E.; Enggist,P.
Helvetica Chimica Acta, 1978 , vol. 61, p. 1335 - 1341
