4'-氯-5-甲氧基-[1,1'-联苯]-3-乙酸合成路线 （共 12 条）
反应条件
sodium hydroxide in methanol
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl
2: POCl3, Na2CO3 / toluene
3: Na / toluene
4: Br2 / benzene
5: aq. NaOH / methanol
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: POCl3, Na2CO3 / toluene
2: Na / toluene
3: Br2 / benzene
4: aq. NaOH / methanol
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: Br2 / benzene
2: aq. NaOH / methanol
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: Na / toluene
2: Br2 / benzene
3: aq. NaOH / methanol
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: aq. NaOH
2: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl
3: POCl3, Na2CO3 / toluene
4: Na / toluene
5: Br2 / benzene
6: aq. NaOH / methanol
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: aq. HBr, AcOH
2: H2SO4 / benzene
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
hydrogen bromide; acetic acid
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
(i) SOCl2, benzene, (ii) aq. NH3; Multistep reaction;
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
sulfuric acid in benzene
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
