3-甲氧基-5-甲基苯乙酸合成路线 （共 4 条）
反应条件
1: 3,5-Dimethylanisole With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane
T=-78°C; Inert atmosphere;
2: carbon dioxide in tetrahydrofuran; hexane
Inert atmosphere; regioselective reaction;
参考文献
Fleming, Patricia; Oshea, Donal F.
Journal of the American Chemical Society, 2011 , vol. 133, # 6 p. 1698 - 1701
反应条件
1: 67 percent / N-bromosuccinimide / azobisisobutyronitrile / CCl4 / 1 h / Heating; irradiation
2: 91 percent / 1-methyl-pyrrolidin-2-one / 20 °C
3: 99 percent / aq. KOH / ethanol / 11 h / Heating
View Scheme
参考文献
Rogers, Daniel H.; Frey, Barbara; Roden, Francis S.; Russkamp, Friedrich-Wilhelm; Willis, Anthony C.; Mander, Lewis N.
Australian Journal of Chemistry, 1999 , vol. 52, # 11 p. 1093 - 1108
反应条件
sodium hydroxide in methanol
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: 91 percent / 1-methyl-pyrrolidin-2-one / 20 °C
2: 99 percent / aq. KOH / ethanol / 11 h / Heating
View Scheme
参考文献
Rogers, Daniel H.; Frey, Barbara; Roden, Francis S.; Russkamp, Friedrich-Wilhelm; Willis, Anthony C.; Mander, Lewis N.
Australian Journal of Chemistry, 1999 , vol. 52, # 11 p. 1093 - 1108
