5-(羟基甲基)-3-吡啶醇合成路线 （共 5 条）
反应条件
cyclohexa-1,4-diene; palladium in methanol
T=20°C; 3 h;
参考文献
Rommel, Michael; Ernst, Alexander; Koert, Ulrich
European Journal of Organic Chemistry, 2007 , # 26 p. 4408 - 4430
反应条件
1: With sodium nitrite
0.5 h;
2: With sulfuric acid
T=70°C; 1 h; Further stages.;
参考文献
Jensen, Henrik Helligso; Lyngbye, Laila; Jensen, Astrid; Bols, Mikael
Chemistry - A European Journal, 2002 , vol. 8, # 5 p. 1218 - 1226
反应条件
1.1: 1.82 g / acetic anhydride; various solvent(s) / 48 h / Heating
2.1: 93 percent / LiAlH4 / tetrahydrofuran / 21 h / 20 °C
3.1: NaNO2 / 0.5 h
3.2: 83 percent / aq. H2SO4 / 1 h / 70 °C
View Scheme
参考文献
Jensen, Henrik Helligso; Lyngbye, Laila; Jensen, Astrid; Bols, Mikael
Chemistry - A European Journal, 2002 , vol. 8, # 5 p. 1218 - 1226
反应条件
1.1: CuSO4*5H2O; aq. NH3 / 24 h / 180 °C
2.1: 1.82 g / acetic anhydride; various solvent(s) / 48 h / Heating
3.1: 93 percent / LiAlH4 / tetrahydrofuran / 21 h / 20 °C
4.1: NaNO2 / 0.5 h
4.2: 83 percent / aq. H2SO4 / 1 h / 70 °C
View Scheme
参考文献
Jensen, Henrik Helligso; Lyngbye, Laila; Jensen, Astrid; Bols, Mikael
Chemistry - A European Journal, 2002 , vol. 8, # 5 p. 1218 - 1226
反应条件
1.1: 93 percent / LiAlH4 / tetrahydrofuran / 21 h / 20 °C
2.1: NaNO2 / 0.5 h
2.2: 83 percent / aq. H2SO4 / 1 h / 70 °C
View Scheme
参考文献
Jensen, Henrik Helligso; Lyngbye, Laila; Jensen, Astrid; Bols, Mikael
Chemistry - A European Journal, 2002 , vol. 8, # 5 p. 1218 - 1226
