N-苄氧羰基-4-氨基丁酸合成路线 （共 42 条）
反应条件
dicyclohexyl-carbodiimide in dichloromethane Ambient temperature;
参考文献
Mera, Ann E.; Griffith, James R.; Baum, Kurt
Journal of Fluorine Chemistry, 1990 , vol. 49, # 3 p. 313 - 320
反应条件
4-(N,N-dimethlyamino)pyridine; ethyl acetate; triethylamine T=20°C; 3 h;
参考文献
Cardenal, Carmen; Vollrath, Sidonie B. L.; Schepers, Ute; Braese, Stefan
Helvetica Chimica Acta, 2012 , vol. 95, # 11 p. 2237 - 2248
反应条件
1.1: RO-CO-Cl (R = Bn or i-Bu); Et3N / diethyl ether; tetrahydrofuran / 0.5 h / -20 °C 1.2: diethyl ether; tetrahydrofuran / 4 h / -10 - 20 °C 2.1: 76 percent / Cu(acac)2 / benzene / 1.5 h / Heating View Scheme
参考文献
Wang, Jianbo; Hou, Yihua; Wu, Peng
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 16 p. 2277 - 2280
反应条件
methanol; sodium methylate Electrolysis;
参考文献
Linstead et al.
Journal of the Chemical Society, 1951 , p. 2854,2856
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Gutierrez-Abad, Raquel; Illa, Ona; Ortuno, Rosa M.
Organic Letters, 2010 , vol. 12, # 14 p. 3148 - 3151
反应条件
in methanol; diethyl ether
T=20°C; 1 h;
参考文献
Kaname, Mamoru; Yoshifuji, Shigeyuki; Sashida, Haruki
Tetrahedron Letters, 2008 , vol. 49, # 17 p. 2786 - 2788
反应条件
1: 68 percent / DCC; Et3N / CH2Cl2 / 16 h / 20 °C
2: 75 percent / aq. NaOH / methanol / 16 h / 20 °C
3: 89 percent / DCC; EtN / CH2Cl2 / 16 h / 20 °C
4: 70 percent / aq. NaOH / methanol / 16 h / 20 °C
View Scheme
参考文献
Rosowsky, Andre; Forsch, Ronald A.; Freisheim, James H.; Danenberg, Peter V.; Moran, Richard G.; Wick, Michael M.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1872 - 1876
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 24 h;
参考文献
Kinney, William A.; Lawson, Edward C.; Ghosh, Shyamali; Luci, Diane K.; McComsey, David F.
Patent: US2008/318973 A1, 2008 ;
Location in patent: Page/Page column 53 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane
18 h; Ambient temperature;
参考文献
Muller, Dan; Zeltser, Irena; Bitan, Gal; Gilon, Chaim
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 411 - 416
反应条件
N-benzyl-N,N,N-triethylammonium chloride in N,N-dimethyl acetamide
T=55°C;
参考文献
Dijols; Perollier; Lefevre-Groboillot; Pethe; Attias; Boucher; Stuehr; Mansuy
Journal of Medicinal Chemistry, 2001 , vol. 44, # 20 p. 3199 - 3202
