(4-吡啶-2-苯基)-乙酸合成路线 （共 7 条）
反应条件
water; sodium hydroxide in toluene
T=55 - 60°C; 4 h;
参考文献
AiCuris GmbH and Co. KG; Schwab, Wilfried; Birkmann, Alexander; Vögtli, Kurt; Haag, Dieter Dr.; Lender, Andreas Dr.; Grunenberg, Alfons Dr.; Keil, Birgit D.-I.; Rehse, Joachim Dr.
Patent: EP2573086 A1, 2013 ;
Location in patent: Paragraph 0070 ;
反应条件
water; sodium hydroxide
T=10 - 55°C; 4 h;
参考文献
AICURIS GMBH and CO. KG; SCHWAB, Wilfried; BIRKMANN, Alexander; VÖGTLI, Kurt; HAAG, Dieter; LENDER, Andreas; GRUNENBERG, Alfons; KEIL, Birgit; REHSE, Joachim
Patent: WO2013/45479 A1, 2013 ;
Location in patent: Page/Page column 21-22 ;
反应条件
hydrogenchloride
48 h; Heating;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: NBS, benzoyl peroxide / CCl4 / Heating
2: acetonitrile / 3 h / Ambient temperature
3: aq. HCl / 48 h / Heating
View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: acetonitrile / 3 h / Ambient temperature
2: aq. HCl / 48 h / Heating
View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 1 - 1.5 h / 90 - 95 °C / |Inert atmosphere
1.2: 2 h / 90 - 95 °C / |Inert atmosphere
1.3: 10 °C / |Inert atmosphere
2.1: water; sodium hydroxide / toluene / 4 h / 55 - 60 °C
View Scheme
参考文献
AiCuris GmbH and Co. KG; Schwab, Wilfried; Birkmann, Alexander; Vögtli, Kurt; Haag, Dieter Dr.; Lender, Andreas Dr.; Grunenberg, Alfons Dr.; Keil, Birgit D.-I.; Rehse, Joachim Dr.
Patent: EP2573086 A1, 2013 ;
反应条件
1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 1 - 1.5 h / 90 - 95 °C / |Inert atmosphere
1.2: 2 h / 90 - 95 °C / |Inert atmosphere
1.3: 10 °C / |Inert atmosphere
2.1: water; sodium hydroxide / toluene / 4 h / 55 - 60 °C
View Scheme
参考文献
AiCuris GmbH and Co. KG; Schwab, Wilfried; Birkmann, Alexander; Vögtli, Kurt; Haag, Dieter Dr.; Lender, Andreas Dr.; Grunenberg, Alfons Dr.; Keil, Birgit D.-I.; Rehse, Joachim Dr.
Patent: EP2573086 A1, 2013 ;
