2-苯基吡唑并[1,5-a]吡啶-3-羧酸乙酯合成路线 （共 7 条）
反应条件
potassium carbonate
T=20°C; 18 h;
参考文献
ARRAY BIOPHARMA INC.; ALLEN, Shelley; BRANDHUBER, Barbara J.; CONDROSKI, Kevin Ronald; HUANG, Lily; KERCHER, Timothy; WINSKI, Shannon L.
Patent: WO2014/78408 A1, 2014 ;
Location in patent: Paragraph 00673 ;
反应条件
potassium carbonate in chloroform
24 h; Ambient temperature;
参考文献
Kakehi, Akikazu; Ito, Suketaka; Nagata, Kenji; Kinoshita, Naosumi; Kakinuma, Noboru
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 156 - 169
反应条件
1: 75 percent / anhydrous K2CO3 / ethanol / 24 h / Ambient temperature
2: CHCl3 / Ambient temperature
3: 97 percent / anhydrous K2CO3 / CHCl3 / 24 h / Ambient temperature
View Scheme
参考文献
Kakehi, Akikazu; Ito, Suketaka; Nagata, Kenji; Kinoshita, Naosumi; Kakinuma, Noboru
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 156 - 169
反应条件
1: CHCl3 / Ambient temperature
2: 97 percent / anhydrous K2CO3 / CHCl3 / 24 h / Ambient temperature
View Scheme
参考文献
Kakehi, Akikazu; Ito, Suketaka; Nagata, Kenji; Kinoshita, Naosumi; Kakinuma, Noboru
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 156 - 169
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling
2: manganese(IV) oxide / tetrahydrofuran / 1.5 h / Reflux
View Scheme
参考文献
Zanka, Atsuhiko; Uematsu, Ryoichi; Morinaga, Yasuhiro; Yasuda, Hironobu; Yamazaki, Hiroshi
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 389 - 393
反应条件
potassium hydroxide
1) water, 30 min, reflux, 2) 95percent ethanol, 20 min, reflux, 3) HCl;
参考文献
Anderson, Paul L.; Hasak, James P; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1149 - 1152
反应条件
hydrogen bromide in water
参考文献
Zanka, Atsuhiko; Uematsu, Ryoichi; Morinaga, Yasuhiro; Yasuda, Hironobu; Yamazaki, Hiroshi
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 389 - 393
