N-(3-甲基-1-氧代-1-{2-[(2-氧代-1(2H)-萘亚基)甲基]肼基}-2-丁烷基)-2,2-二苯基乙酰胺合成路线 （共 5 条）
反应条件
sodium hydroxide in methanol
T=20°C; 24 h;
参考文献
Singh, Prabhpreet
Journal of Chemical Sciences, 2014 , vol. 126, # 1 p. 159 - 167
反应条件
1: 76 percent / TEA / CH2Cl2 / 3.5 h / 5 - 20 °C
2: 68 percent / 1M aq. LiOH / tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Jung, Manfred; Brosch, Gerald; Koelle, Doris; Scherf, Hans; Gerhaeuser, Clarissa; Loidl, Peter
Journal of Medicinal Chemistry, 1999 , vol. 42, # 22 p. 4669 - 4679
参考文献
Wright et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 3014,3015
反应条件
1: thionyl chloride / 7 h / 0 - 20 °C
2: triethylamine / toluene / 12 h / 65 °C / |Inert atmosphere
3: sodium hydroxide / methanol / 24 h / 20 °C
View Scheme
参考文献
Singh, Prabhpreet
Journal of Chemical Sciences, 2014 , vol. 126, # 1 p. 159 - 167
反应条件
1: thionyl chloride; N,N-dimethyl-formamide / 5 h / |Reflux
2: triethylamine / toluene / 12 h / 65 °C / |Inert atmosphere
3: sodium hydroxide / methanol / 24 h / 20 °C
View Scheme
参考文献
Singh, Prabhpreet
Journal of Chemical Sciences, 2014 , vol. 126, # 1 p. 159 - 167
