1,2,3,4,5,6,7,8-八氢-1-[(4-甲氧基苯基)甲基]异喹啉合成路线 （共 6 条）
反应条件
1: methanol; water / Nachfolgenden Hydrieren an Raney-Nickel 2: phosphoric acid View Scheme
参考文献
Schnider; Hellerbach
Helvetica Chimica Acta, 1950 , vol. 33, p. 1437,1447
反应条件
1: (-)-Naproxen; (+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide With sodium hydroxide in water; toluene
T=10 - 15°C; pH=12 - 13;
2: (-)-Naproxen in toluene
T=6 - 55°C; Resolution of racemate;
参考文献
Divi's Laboratories, Ltd.
Patent: US8148527 B1, 2012 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium hydroxide in water; toluene
T=10 - 15°C; pH=12 - 13;
参考文献
Divi's Laboratories Limited; Divi, Murali. Krishna, Prasad; Rao, Pendyala, Srinivas; Ramana, Lavu, Venkata
Patent: EP2628728 A1, 2013 ;
Location in patent: Paragraph 0021 ;
反应条件
sodium hydroxide in water
参考文献
Divi's Laboratories Limited; Divi, Murali. Krishna, Prasad; Rao, Pendyala, Srinivas; Ramana, Lavu, Venkata
Patent: EP2628728 A1, 2013 ;
Location in patent: Paragraph 0032 ;
参考文献
Merck Patent Gesellschaft mit beschrankter Haftung
Patent: US4727147 A1, 1988 ;
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 0.33 h / -14 - -10 °C
2: aq. FeCl2 / CH2Cl2 / 1.) -14 to -10 deg C, 1 h; 2.) room temp., 2 h
View Scheme
参考文献
Monkovic, Ivo; Wong, Henry; Bachand, Carol
Synthesis, 1985 , # 8 p. 770 - 773
