1,2-二甲基-1H-吲哚-3-甲腈合成路线 （共 12 条）
反应条件
oxygen; copper diacetate; palladium diacetate in dimethyl sulfoxide T=130°C; 5 h;
参考文献
Yan, Guobing; Kuang, Chunxiang; Zhang, Yan; Wang, Jianbo
Organic Letters, 2010 , vol. 12, # 5 p. 1052 - 1055
反应条件
1: 2-methylindole-3-carbonitrile With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; 1.25 h; 2: methyl iodide in tetrahydrofuran; mineral oil T=20°C; 0.5 h;
参考文献
Zhang, Line; Ang, Gim Yean; Chiba, Shunsuke
Organic Letters, 2011 , vol. 13, # 7 p. 1622 - 1625
反应条件
boron trifluoride diethyl etherate in 1,2-dichloro-ethane T=80°C; 12 h; Sealed vialInert atmosphere; regioselective reaction;
参考文献
Yang, Yang; Zhang, Yan; Wang, Jianbo
Organic Letters, 2011 , vol. 13, # 20 p. 5608 - 5611
反应条件
aluminium trichloride; sodium azide in tetrahydrofuran 9 h; Heating;
参考文献
Jaisankar, Pichamuthu; Srinivasan
Synthesis, 2006 , # 14 p. 2413 - 2417
反应条件
in 1,2-dichloro-ethane T=20°C; 2 h;
参考文献
Smaliy, Radomir V.; Chaikovskaya, Aleksandra A.; Pinchuk, Aleksandr M.; Tolmachev, Andrei A.
Synthesis, 2002 , # 16 p. 2416 - 2420
反应条件
acetic anhydride 2 h; Reflux;
参考文献
GLAXO GROUP LIMITED; BLUNT, Richard; EATHERTON, Andrew John; GARZYA, Vincenzo; HEALY, Mark Patrick; MYATT, James; PORTER, Roderick Alan
Patent: WO2011/12622 A1, 2011 ;
Location in patent: Page/Page column 78 ;
WO 2011/012622 A1
反应条件
oxygen; tetra-n-butylammonium acetate; palladium diacetate; potassium carbonate; copper(ll) bromide; iron(II) chloride T=130°C; P=760.051 Torr; 24 h;
参考文献
Ding, Shengtao; Jiao, Ning
Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12374 - 12377
反应条件
oxygen; copper diacetate; ammonium hydrogen carbonate; palladium dichloride T=140°C; 6 h; Sealed tube; regioselective reaction;
参考文献
Ren, Xinyi; Chen, Jianbin; Chen, Fan; Cheng, Jiang
Chemical Communications, 2011 , vol. 47, # 23 p. 6725 - 6727
反应条件
in dichloromethane 1.) -40 deg C, 2.) room temperature, overnight;
参考文献
Tamura, Yasumitsu; Adachi, Masahiro; Kawasaki, Tomomi; Yasuda, Hitoshi; Kita, Yasuyuki
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1132 - 1135
反应条件
sodium azide in dimethyl sulfoxide T=120°C; 0.05 h;
参考文献
Becher, Jan; Joergensen, Per Lauge; Pluta, Krystian; Krake, Niels J.; Faelt-Hansen, Birgitte
Journal of Organic Chemistry, 1992 , vol. <7> 57, p. 2127 - 2134
