2,3,4,9-四氢-2-甲基-1-(2-甲基-1-丙烯基)-1H-吡啶并[3,4-b]吲哚合成路线 （共 12 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
5 h; Ambient temperature;
参考文献
May, Jeremy A.; Vallakati, Ravikrishna
Patent: US2013/190511 A1, 2013 ;
Location in patent: Paragraph 0052 ;
反应条件
1: molecular sieves 4A / CH2Cl2 / Ambient temperature
2: pyridine / CH2Cl2 / Ambient temperature
3: 88 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature
View Scheme
参考文献
Yamanaka, Etsuji; Shibata, Naoki; Sakai, Shin-ichiro
Heterocycles, 1984 , vol. 22, # 2 p. 371 - 374
反应条件
1: molecular sieves 4A / CH2Cl2 / Ambient temperature
2: pyridine / CH2Cl2 / Ambient temperature
3: 88 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature
View Scheme
参考文献
Yamanaka, Etsuji; Shibata, Naoki; Sakai, Shin-ichiro
Heterocycles, 1984 , vol. 22, # 2 p. 371 - 374
反应条件
1: 63 percent / conc. HCl / H2O / 288 h / 20 °C
2: 85 percent / diethyl ether / 2 h / Heating
3: 49 percent / pyridine, POCl3 / 48 h / 20 °C
View Scheme
参考文献
Tillequin, Francois; Koch, Michel
Phytochemistry (Elsevier), 1980 , vol. 19, p. 1282 - 1283
反应条件
1: 85 percent / diethyl ether / 2 h / Heating
2: 49 percent / pyridine, POCl3 / 48 h / 20 °C
View Scheme
参考文献
Tillequin, Francois; Koch, Michel
Phytochemistry (Elsevier), 1980 , vol. 19, p. 1282 - 1283
反应条件
1: 87 percent / tetra-n-butylammonium chloride, palladium acetate
2: 86 percent / ammonium acetate
3: 80 percent / sodium borohydride / methanol
4: 50 percent / Zn, HCl / methanol / Heating
5: 85 percent
6: 70 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Somei, Masanori; Sayama, Shinsuke; Naka, Katsumi; Yamada, Fumio
Heterocycles, 1988 , vol. 27, # 7 p. 1585 - 1588
反应条件
1: 87 percent / tetra-n-butylammonium chloride, palladium acetate
2: 86 percent / ammonium acetate
3: 80 percent / sodium borohydride / methanol
4: 50 percent / Zn, HCl / methanol / Heating
5: 85 percent
6: 70 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Somei, Masanori; Sayama, Shinsuke; Naka, Katsumi; Yamada, Fumio
Heterocycles, 1988 , vol. 27, # 7 p. 1585 - 1588
反应条件
1: 85 percent
2: 70 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Somei, Masanori; Sayama, Shinsuke; Naka, Katsumi; Yamada, Fumio
Heterocycles, 1988 , vol. 27, # 7 p. 1585 - 1588
反应条件
1: 86 percent / ammonium acetate
2: 80 percent / sodium borohydride / methanol
3: 50 percent / Zn, HCl / methanol / Heating
4: 85 percent
5: 70 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Somei, Masanori; Sayama, Shinsuke; Naka, Katsumi; Yamada, Fumio
Heterocycles, 1988 , vol. 27, # 7 p. 1585 - 1588
反应条件
1: 80 percent / sodium borohydride / methanol
2: 50 percent / Zn, HCl / methanol / Heating
3: 85 percent
4: 70 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Somei, Masanori; Sayama, Shinsuke; Naka, Katsumi; Yamada, Fumio
Heterocycles, 1988 , vol. 27, # 7 p. 1585 - 1588
