1-Boc-L-吖啶-2-羧酸合成路线 （共 11 条）
反应条件
sodium hydroxide in ethanol T=20°C;
参考文献
Washington University in St. Louis
Patent: US2009/68105 A1, 2009 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogenchloride; sodium methylate; triethylamine in methanol; ethylene glycol dimethyl ether; water; ethyl acetate
参考文献
Nagashima, Nobuo
Patent: US2003/9056 A1, 2003 ;
反应条件
1: With trimethylacetic anhydride; sodium carbonate 12 h; 2: With hydrogenchloride
参考文献
KANEKA CORPORATION
Patent: EP1415985 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
sodium hypochlorite; anhydrous sodium hydrogen carbonate; sulfuric acid; 3'-phenoxy-4'-fluoro-α'-cyanobenzyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropane-carboxylate; sodium thiosulfate; sodium bromide in water; ethyl acetate
参考文献
Kaneka Corporation
Patent: US6150535 A1, 2000 ;
反应条件
triethylamine in water; acetone
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4902684 A1, 1990 ;
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water
参考文献
Abbott Laboratories
Patent: US5914328 A1, 1999 ;
反应条件
triethylamine in 1,4-dioxane; water 24 h; Ambient temperature;
参考文献
Tanaka, Ken-ichi; Yoshifuji, Shigeyuki; Nitta, Yoshihiro
Heterocycles, 1986 , vol. 24, # 9 p. 2539 - 2543
反应条件
triethylamine in 1,4-dioxane; water 4 h; Ambient temperature;
参考文献
Ohfune, Yasufumi; Tomita, Masako; Nomoto, Kyosuke
Journal of the American Chemical Society, 1981 , vol. 103, # 9 p. 2409 - 2410
反应条件
1: With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=-10°C; 0.333333 h; 2: With ammonium hydroxide in tetrahydrofuran; water
参考文献
PFIZER INC.
Patent: WO2007/23382 A2, 2007 ;
Location in patent: Page/Page column 70 ;
WO 2007/023382 A2
反应条件
1: 89 percent / BH3*DMS / tetrahydrofuran / -78 °C 2: 40 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Dolle, Frederic; Valette, Heric; Bottlaender, Michel; Hinnen, Francoise; Vaufrey, Francoise; Guenther, Ilonka; Crouzel, Christian
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 5 p. 451 - 463
