(S)-2-(6-甲氧基-2-萘基)丙酰氯合成路线 （共 9 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 25°C;
参考文献
Huang, Zhangjian; Velazquez, Carlos A.; Abdellatif, Khaled R. A.; Chowdhury, Morshed A.; Reisz, Julie A.; Dumond, Jenna F.; King, S. Bruce; Knaus, Edward E.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1356 - 1364
反应条件
in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
Brantford Chemicals Inc.
Patent: US6380388 B1, 2002 ;
反应条件
oxalyl dichloride in hexane
参考文献
Solis, Aida; Luna, Hector; Perez, Herminia I.; Manjarrez, Norberto; Sanchez, Remedios; Gutierrez, Atilano
Tetrahedron Letters, 1998 , vol. 39, # 48 p. 8759 - 8762
反应条件
1.1: ammonia / dichloromethane / 1 h / pH 10 2.1: sodium hydride / toluene / 5 h / 80 - 90 °C 3.1: hydrogen; 5 palladium on charcoal / toluene / 24 h / 80 °C / 6000.6 Torr 4.1: hydrogenchloride / isopropyl alcohol / 5 h / pH < 2 4.2: pH 10 5.1: potassium hydroxide / methanol / 72 h / |Reflux View Scheme
参考文献
Reddy, G. Prashanth; Bandichhor, Rakeshwar
Asian Journal of Chemistry, 2013 , vol. 25, # 15 p. 8701 - 8707
反应条件
calcium aluminosilicate in dichloromethane T=0 - 20°C; 10 h; Product distribution / selectivity;
参考文献
NICOX S.A.
Patent: EP1200386 B1, 2003 ;
Location in patent: Page/Page column 3 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C; 10 h; Product distribution / selectivity;
参考文献
NICOX S.A.
Patent: EP1200386 B1, 2003 ;
Location in patent: Page/Page column 4 ;
反应条件
in dichloromethane
T=-20°C; 6 h; Resolution of racemate;
参考文献
Gruzdev, Dmitry A.; Chulakov, Evgeny N.; Levit, Galina L.; Ezhikova, Marina A.; Kodess, Mikhail I.; Krasnov, Victor P.
Tetrahedron Asymmetry, 2013 , vol. 24, # 19 p. 1240 - 1246
反应条件
in dichloromethane
T=20°C; 6 h; Resolution of racemate;
参考文献
Gruzdev, Dmitry A.; Chulakov, Evgeny N.; Levit, Galina L.; Ezhikova, Marina A.; Kodess, Mikhail I.; Krasnov, Victor P.
Tetrahedron Asymmetry, 2013 , vol. 24, # 19 p. 1240 - 1246
反应条件
1: 85 percent / triethylamine / CH2Cl2 / 0.25 h / -10 °C
2: 85 percent / Br2 / 1,2-dichloro-ethane / 0.75 h / 0 °C
3: 95 percent / CH3COOH, concd. HCl, water / 85 °C
View Scheme
参考文献
Castaldi, Graziano; Cavicchioli, Silvia; Giordano, Claudio; Uggeri, Fulvio
Journal of Organic Chemistry, 1987 , vol. 52, # 14 p. 3018 - 3027
